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The association between the HLA antigens and Takayasu's arteritis in Thai patients
P Charoenwongse1, O Kangwanshiratada, R Boonnam
1Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
The HLA-A, -B, -DR and -DQ antigen distribution in 20 unrelated Thai patients with Takayasu's arteritis was compared with that in 44 healthy controls. The frequency of HLA-A31 and HLA-B52 (chi2=4.54, P<0.05; chi2=3.80, P<0.05, RR=7.5) appeared to be increased in the patient group. In contrast, the frequency of HLA-A24 and HLA-DQ3 (chi2=4.18, P<0.05, RR=0.25; chi2=5.36, P<.025, RR=0.28) appeared to be decreased in this group.
The HLA-A, -B, -DR and -DQ antigen distribution in 20 unrelated Thai patients with Takayasu's arteritis was compared with that in 44 healthy controls. The frequency of HLA-A31 and HLA-B52 (chi2=4.54, P<0.05; chi2=3.80, P<0.05, RR=7.5) appeared to be increased in the patient group. In contrast, the frequency of HLA-A24 and HLA-DQ3 (chi2=4.18, P<0.05, RR=0.25; chi2=5.36, P<.025, RR=0.28) appeared to be decreased in this group.