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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Risk factors influencing the outcome of portal and mesenteric vein thrombosis

T Berney1, M Morales, P E Broquet

  • 1Clinic of Digestive Surgery, Geneva University Hospital, Switzerland.

Hepato-Gastroenterology
|February 10, 1999
PubMed
Abstract

Insights

Portal and superior mesenteric vein thrombosis (PMVT) outcomes differ significantly by etiology. Cirrhosis increases gastrointestinal bleeding risk and mortality, while idiopathic cases show better survival and tolerate anticoagulation.

Area of Science:

  • Gastroenterology
  • Vascular Medicine
  • Hepatology

Background:

  • Portal and superior mesenteric vein thrombosis (PMVT) is a serious condition with variable outcomes.
  • Etiological factors significantly impact the course and prognosis of PMVT.

Purpose of the Study:

  • To analyze risk factors influencing the course and outcome of portal and superior mesenteric vein thrombosis (PMVT).
  • To compare outcomes between different etiological groups of PMVT.

Main Methods:

  • Retrospective review of 45 patients diagnosed with PMVT over 17 years.
  • Classification of patients into etiological groups: cirrhosis (47%), pancreatitis (22%), and other causes (33%).

Main Results:

  • Cirrhotic patients had higher rates of gastric/esophageal variceal rupture (75% vs. 17%) and mortality.
  • Actuarial 5-year survival was 43%, significantly lower in cirrhosis, malignancy, or hematemesis.
  • Gastrointestinal bleeding and malignancy were responsible for 50% of deaths.

Conclusions:

  • Cirrhosis is associated with poor outcomes and increased gastrointestinal bleeding, the primary cause of mortality in PMVT.
  • Non-cirrhotic and idiopathic PMVT cases exhibit better survival and are suitable for anticoagulative therapy.

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