Male monozygotic twins discordant for periventricular nodular heterotopia and epilepsy
S M Sisodiya1, W Marques, A Everitt
1Department of Neurology, Radcliffe Infirmary, Oxford, England.
Purpose:
To determine zygosity and study cerebral structure in apparently identical twins with discordant manifestation of focal epilepsy.
Methods:
Male twins in their fifth decade were scanned by using magnetic resonance imaging (MRI) to detect structural abnormalities. Zygosity was determined by using 10 microsatellite markers.
Results:
DNA analysis showed that the twins were >99.99% likely to be monozygous; they were discordant for bilateral symmetric periventricular nodular heterotopia (PNH) and epilepsy.
Conclusions:
The discordant occurrence of PNH and epilepsy in monozygotic male twins carries implications with respect to somatic mosaicism, currently held to be responsible for PNH in affected male subjects.
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