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Improvement of biliary excretion of ioglycamide by pretreatment with phenobarbital
Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
|October 29, 1976
Abstract:
The influence of a phenobarbital pretreatment on the distribution and biliary excretion of Ioglycamide was studied in 6 experiments in the anaesthetized minipig. The phenobarbital pretreatment led to a significant increase of the biliary transportmaximum and the biliary concentration of Ioglycamide. A detailed analysis suggests a phenobarbital induced stimulation of the hepatocellular excretion. The applicability of a pretreatment with phenobarbital in order to improve the opacification of the biliary system during x-ray-examinations with Ioglycamide is discussed.