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Acid-base patterns in lean and obese subjects during total fasting

H Göschke, A Perruchoud, R Keller

    Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
    |October 29, 1976
    PubMed
    Summary

    Lean females exhibit greater acidosis during prolonged fasting compared to males. Severe obesity eliminates this sex difference in acid-base status, highlighting the need for blood gas monitoring in all fasting patients.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Clinical Medicine

    Background:

    • Prolonged fasting can alter acid-base balance.
    • Sex-based differences in physiological responses to fasting are not well-established.
    • Obesity's impact on metabolic responses to starvation requires further investigation.

    Purpose of the Study:

    • To investigate sex differences in acid-base status during prolonged starvation.
    • To determine if obesity modifies these sex-based differences.
    • To assess the incidence of acidosis in obese patients undergoing fasting.

    Main Methods:

    • Blood gas analyses were performed on lean and obese subjects during prolonged starvation.
    • Subjects included 24 lean individuals and 78 obese patients.

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  • Fasting durations ranged from 1 to 4 weeks.

    • Main Results:

    • Lean females showed significantly higher acidosis after 4-6 days of fasting compared to lean males.
    • This sex difference in acid-base status was abolished in severely obese individuals.
    • Eight out of 78 obese patients experienced pH values below 7.30 during fasting.

    Conclusions:

    • A sex difference in acid-base status exists in lean individuals during prolonged fasting.
    • Severe obesity mitigates this sex difference.
    • Regular blood gas analysis is recommended for all patients undergoing prolonged total fasting.