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[Ovulation inhibitors from a neurological viewpoint]

J Gschwend

    Schweizerische Medizinische Wochenschrift
    |May 1, 1976
    PubMed
    Summary

    Aspirin may prevent cerebral thrombosis in women using oral contraceptives, which increase stroke risk. Further prospective studies are needed to confirm Aspirin

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    Area of Science:

    • Neurology
    • Pharmacology
    • Cardiovascular Medicine

    Context:

    • Oral contraceptives are linked to increased risk of thromboembolic diseases, particularly cerebral ictus (stroke).
    • The hemostatic mechanisms affected by oral contraceptives may promote intimal proliferation, contributing to thrombosis.
    • Aspirin has demonstrated antithrombotic activity and efficacy in preventing arterial thrombosis since 1968.

    Purpose:

    • To investigate the potential of Aspirin in preventing cerebral thrombosis among women using oral contraceptives.
    • To explore the hypothesis that Aspirin's antithrombotic properties can counteract the pro-thrombotic effects of oral contraceptives.

    Summary:

    • A study examined six women with cerebral ictus, noting a significantly higher incidence in women using oral contraceptives.
    • Diagnostic imaging (X-ray, ECG, pulmonary scintigraphy, arteriography) ruled out pulmonary or cardiac thrombosis, suggesting primary cerebral thrombosis.
    • The findings support the hypothesis that Aspirin, at doses up to 1g daily, may be effective in preventing stroke in this population.

    Impact:

    • This research suggests a potential preventative strategy for stroke in women using oral contraceptives.
    • The findings highlight the need for prospective studies to validate Aspirin's efficacy and safety in this context.
    • Understanding the interplay between oral contraceptives, hemostasis, and stroke risk can inform clinical practice and patient counseling.
    Keywords:
    Clinical ResearchDiseasesEmbolismOral ContraceptivesResearch MethodologyThromboembolismVascular Diseases

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