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[Hirsutism]

A Labhart

    Schweizerische Medizinische Wochenschrift
    |September 4, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Hirsutism, or increased male-pattern hair growth, is influenced by genetics and hormones. The ovary, not the adrenal cortex, is the primary source of testosterone, impacting hirsutism treatment.

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    Area of Science:

    • Endocrinology
    • Dermatology

    Background:

    • Hirsutism is defined as increased masculine-type sexual hair growth.
    • It is distinct from hypertrichosis (generalized hair increase) and virilism (masculinizing organ changes).
    • Hirsutism is influenced by age, race, heredity, hair follicle sensitivity, and androgen levels.

    Purpose of the Study:

    • To clarify the origins of testosterone and androstanedione relevant to hirsutism.
    • To review current and potential treatment modalities for hirsutism.

    Main Methods:

    • Distinguishing hirsutism from related conditions.
    • Identifying the primary source of testosterone and androstanedione via catheterization studies.
    • Evaluating external treatments and hormonal therapies for hirsutism.

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    Main Results:

    • Catheterization studies indicate the ovary is the main source of testosterone and androstanedione, challenging previous assumptions about the adrenal cortex.
    • External treatments like plucking and shaving are suitable for mild hirsutism.
    • Corticoids can treat amenorrhea associated with hirsutism, yielding limited regression (one-third) over time.
    • Reverse-sequence therapy with cyproterone acetate and ethinyl estradiol shows good results but is costly and has side effects.

    Conclusions:

    • The ovary is the principal source of androgens contributing to hirsutism.
    • Treatment strategies vary from external methods for mild cases to hormonal therapies for severe or complex presentations.
    • Combined anti-androgen and estrogen therapy offers efficacy but requires careful consideration due to cost and potential side effects.