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Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity
Science (New York, N.Y.)
|December 10, 1976
Abstract:
A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells