Cardiovascular malformations in Oryzias latipes embryos treated with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)

Exposure of fertilized Oryzias latipes eggs to concentrations of 2,4,5-trichlorophenoxyacetic acid up to 14 ppm had no gross developmental effects. Exposure to concentrations above 14 ppm resulted in multiple malformations of the heart and blood vessels. Embryos failed to hatch when exposed to concentrations above 25 ppm.