Related Experiment Videos
Anti-calculus activity of a toothpaste with microgranules
R K Chesters1, D M O'Mullane, A Finnerty
1Unilever Dental Research, Port Sunlight Laboratory, Wirral, Merseyside, UK.
Oral Diseases
|February 11, 1999
Summary
This study found that a new toothpaste formulation effectively reduced supragingival calculus by 30% compared to a control. The advanced delivery system for zinc citrate trihydrate did not compromise its anti-calculus efficacy.
Area of Science:
- Oral hygiene research
- Dental materials science
Background:
- Supragingival calculus formation is a common dental issue.
- Effective anticalculus agents are crucial for maintaining oral health.
- Zinc citrate trihydrate (ZCT) and triclosan are proven anticalculus agents.
Purpose of the Study:
- To evaluate the efficacy of a novel toothpaste formulation containing ZCT delivered via microgranules.
- To assess the anticalculus effect of ZCT in a silica-based toothpaste with 1450 ppm fluoride.
Main Methods:
- A monadic, single-blind, two-phase clinical trial was conducted.
- Participants used either the test toothpaste or a control toothpaste for 13 weeks.
- Calculus formation was measured using the Volpe-Manhold index (VMI).
Main Results:
- The test toothpaste demonstrated a statistically significant 30% reduction in supragingival calculus compared to the control.
- No adverse events were reported during the study period.
- The VMI scores indicated significant anticalculus efficacy for the test formulation.
Conclusions:
- Incorporating ZCT into microgranules within the new toothpaste formulation maintained its anticalculus activity.
- The tested toothpaste is effective in reducing calculus formation.
- The formulation is safe for use in oral hygiene practices.