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Related Experiment Videos

Quinine-induced hepatotoxicity

D K Farver1, M N Lavin

  • 1College of Pharmacy, South Dakota State University, Sacred Heart Hospital, Yankton 57078, USA. dfarver@sunflowr.usd.edu

The Annals of Pharmacotherapy
|February 11, 1999
PubMed
Summary
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Quinine can cause rapid-onset liver damage (hepatotoxicity), even after a single dose. Promptly discontinuing quinine is crucial for symptom resolution and normalizing liver enzymes.

Area of Science:

  • Hepatology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Quinine is commonly used for muscle cramps.
  • Hepatotoxicity is a known adverse effect of quinidine, the isomer of quinine.
  • The potential for quinine-induced hepatotoxicity requires further investigation.

Observation:

  • A 57-year-old woman presented with nausea, vomiting, myalgia, fever, and elevated liver enzymes after her first dose of quinine.
  • Liver enzyme levels (alkaline phosphatase, LDH, AST, ALT, GGT) were significantly elevated.
  • Symptoms and liver enzyme levels improved within 48-72 hours of quinine discontinuation.

Findings:

  • This case demonstrates rapid-onset quinine-induced hepatotoxicity.
  • The patient experienced severe symptoms and biochemical evidence of liver injury.

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  • Recovery was observed upon cessation of quinine therapy.

    • Implications:

    • Clinicians should consider quinine as a potential cause of acute liver injury.
    • Increased awareness of quinine hepatotoxicity is necessary for prompt diagnosis and management.
    • This case highlights the importance of considering drug-induced liver injury in patients presenting with unexplained hepatitis.