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Related Experiment Videos

Tenoxicam does not alter renal function during anaesthesia in normal individuals

G M Slaven1, R J Walker, M Zacharias

  • 1Department of Anaesthesia and Intensive Care, Dunedin School of Medicine, New Zealand.

Australian and New Zealand Journal of Medicine
|February 11, 1999
PubMed
Summary

Tenoxicam, a non-steroidal anti-inflammatory drug (NSAID), did not adversely affect kidney function in healthy individuals undergoing surgery. Post-operative renal function returned to normal within six hours, indicating its safety for pain management.

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Area of Science:

  • Anesthesiology
  • Nephrology
  • Pharmacology

Background:

  • Anesthesia and surgery can impair kidney function.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) may exacerbate renal compromise by inhibiting prostaglandin synthesis.
  • Investigating the impact of NSAIDs during anesthesia on renal health is crucial.

Purpose of the Study:

  • To evaluate the effects of tenoxicam, an NSAID, on renal function when administered before anesthesia.
  • To assess renal function in healthy patients undergoing routine surgery after receiving tenoxicam.

Main Methods:

  • A randomized, single-blind, placebo-controlled study was conducted.
  • Twenty healthy patients (ASA I) undergoing lower spinal surgery received either tenoxicam (40 mg IV) or a placebo.

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  • Glomerular filtration rate (GFR) and renal tubular function (osmolar and free water clearance) were measured.

    • Main Results:

    • GFR decreased by 60% during surgery but recovered to pre-operative levels within six hours post-operatively.
    • No significant differences in GFR changes were observed between the tenoxicam and placebo groups.
    • Tenoxicam did not alter renal tubular function.

    Conclusions:

    • Administering NSAIDs like tenoxicam prior to anesthesia appears safe for renal function in low-risk surgical patients.
    • Current clinical use of NSAIDs for post-operative pain relief in healthy individuals shows no adverse renal effects.
    • The findings support the use of NSAIDs for post-operative analgesia in this patient population.