Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The aryl hydrocarbon receptor: a comparative perspective

M E Hahn1

  • 1Biology Department, Woods Hole Oceanographic Institution, MA 02543-1049, USA. mhahn@whoi.edu

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
|February 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARγ.

Aquatic toxicology (Amsterdam, Netherlands)·2019
Same author

Some comments in defense of non-nondirective counseling.

Journal of consulting psychology·2010
Same author

The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.

Developmental biology·2006
Same author

Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness.

Journal of molecular endocrinology·2006
Same author

Biological activity and physicochemical parameters of marine halogenated natural products 2,3,3',4,4',5,5'-heptachloro-1'-methyl-1,2'-bipyrrole and 2,4,6-tribromoanisole.

Archives of environmental contamination and toxicology·2005
Same author

Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models.

Marine biotechnology (New York, N.Y.)·2004

The aryl hydrocarbon receptor (AHR) regulates genes for detoxification. This review compares AHR pathways across species, exploring its presence in early vertebrates and invertebrates.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Toxicology

Background:

  • The aryl hydrocarbon receptor (AHR) is a transcription factor regulating xenobiotic metabolism.
  • AHR ligands include toxic aromatic hydrocarbons like dioxins.
  • AHR and ARNT are part of the bHLH-PAS family of proteins.

Purpose of the Study:

  • To review the AHR signal transduction pathway in non-mammalian species.
  • To compare AHR pathways in non-traditional species with those in rodents and humans.
  • To examine the presence and function of AHR in early vertebrates and invertebrates.

Main Methods:

  • Literature review
  • Comparative analysis of AHR pathways
  • Evolutionary relationship assessment

Related Experiment Videos

Main Results:

  • AHR pathways show similarities and differences across species.
  • Evidence suggests a functional AHR in early vertebrates and invertebrates.
  • AHR and ARNT have diverse functional and evolutionary relationships within the bHLH-PAS family.

Conclusions:

  • The AHR pathway is conserved yet diverse across the animal kingdom.
  • Further research into comparative AHR biochemistry and molecular biology is warranted.
  • Understanding AHR in diverse species aids in assessing environmental risks.