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Related Experiment Video

Updated: Jul 9, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

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Published on: February 14, 2014

[Apolipoproteins and cognitive deterioration]

D Bartrés-Faz1, I Clemente

  • 1Departamento de Psiquiatría y Psicobiología Clínica, Universidad de Barcelona.

Actas Luso-Espanolas De Neurologia, Psiquiatria Y Ciencias Afines
|February 11, 1999
PubMed
Summary
This summary is machine-generated.

Apolipoprotein E (ApoE) gene variations are linked to cognitive decline, particularly memory impairment and Alzheimer's Disease (AD). ApoE epsilon 4 increases AD risk, while other apolipoproteins' roles in brain health remain unclear.

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Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Context:

  • Apolipoprotein genes influence human neuropsychological functions.
  • Apolipoprotein E (ApoE) is particularly relevant to Central Nervous System (CNS) functions, especially memory.

Purpose:

  • To review studies associating apolipoprotein gene variations with neuropsychological impairment.
  • To highlight the role of ApoE in memory and CNS health.

Summary:

  • Apolipoprotein E (ApoE) epsilon 4 is a known risk factor for late-onset Alzheimer's Disease (AD).
  • ApoE genotype influences memory changes in aging individuals and AD patients.
  • ApoE may affect neural structures crucial for memory and is implicated in cerebrovascular disorders like Vascular Dementia (VD) and Multi-infarct Dementia (MD).
  • The impact of other apolipoproteins on cognitive impairment is currently unknown.

Impact:

  • Provides insights into the genetic underpinnings of cognitive decline and dementia.
  • Identifies ApoE as a key player in memory function and neurodegenerative diseases.
  • Suggests potential avenues for future research into apolipoproteins and CNS pathologies.