Related Experiment Videos
Hemorheological alterations and hypercoagulable state in deep vein thrombosis
1Hemorheology Unit, Clinical Pathology, LA FE Hospital, Valencia, Spain.
Clinical Hemorheology and Microcirculation
|February 11, 1999
Summary
Deep vein thrombosis (DVT) is linked to blood clotting and flow issues. These hemorheological and hypercoagulable states persist even after treatment, suggesting they contribute to DVT development.
Area of Science:
- Hematology
- Vascular Medicine
- Thrombosis Research
Background:
- Deep vein thrombosis (DVT) is associated with hypercoagulable states and hemorheological alterations.
- The specific role of these factors in DVT development remains unclear.
Purpose of the Study:
- To investigate the relationship between hemorheological parameters, hypercoagulability, and DVT.
- To assess changes in these markers over time in DVT patients.
Main Methods:
- Studied 55 DVT patients, measuring prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin III complex (T-AT) for hypercoagulability.
- Evaluated key hemorheological parameters acutely, and at 6 and 12 months post-diagnosis.
Main Results:
- Significant hemorheological, F1+2, and T-AT alterations were observed during the acute phase of DVT.
- After 12 months, erythrocyte aggregation, fibrinogen, F1+2, and T-AT remained elevated compared to controls.
- A modest improvement in some parameters was noted, but significant alterations persisted.
Conclusions:
- The study suggests that pre-existing hemorheological conditions and hypercoagulable states may influence DVT occurrence.
- Persistent alterations indicate a potential long-term impact on thrombotic risk in DVT patients.