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Related Experiment Videos

Small centrum ovale infarcts--a pathological study

G A Lammie1, J M Wardlaw

  • 1Department of Neuropathology, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Cerebrovascular Diseases (Basel, Switzerland)
|February 12, 1999
PubMed
Summary

Small centrum ovale infarcts (SCOIs) are pathologically diverse, often stemming from embolic events rather than small vessel disease. Identifying potential cardiac or large vessel sources is crucial for clinical management.

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Area of Science:

  • Neuropathology
  • Cerebrovascular Disease

Background:

  • Limited clinical and radiological data exist for small centrum ovale infarcts (SCOIs).
  • Autopsy studies are essential for detailed pathological examination of cerebrovascular lesions.

Purpose of the Study:

  • To pathologically characterize small centrum ovale infarcts (SCOIs).
  • To investigate the underlying pathogenetic mechanisms of SCOIs.
  • To evaluate the appropriateness of the term 'lacune' for SCOIs.

Main Methods:

  • Examination of 159 consecutive autopsy brains.
  • Gross pathological identification of 21 small centrum ovale infarcts (SCOIs) in 12 cases.
  • Histological analysis of infarcts.
  • Review of clinicopathological data to determine embolic sources.

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Main Results:

  • Majority of SCOIs showed incomplete infarction histologically.
  • Potential embolic sources identified in 10 out of 12 cases (cardioembolic, aortic arch, or carotid artery atheroma).
  • Most lesions located in arterial borderzones.

Conclusions:

  • Small centrum ovale infarcts (SCOIs) are pathologically and pathogenetically heterogeneous.
  • The term 'lacune' is inappropriate for SCOIs due to diverse etiologies.
  • Clinical evaluation should exclude treatable cardiac and large vessel pathologies.