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Mastodynon(R) bei weiblicher Sterilität
Forschende Komplementarmedizin
|February 12, 1999
Summary
Mastodynon, a preparation containing Agnus castus, showed a higher pregnancy rate in women with infertility due to secondary amenorrhea and luteal insufficiency compared to placebo. Treatment over 3-6 months is recommended.
Area of Science:
- Reproductive Medicine
- Phytotherapy
- Clinical Trials
Background:
- Female infertility affects numerous women globally.
- Conventional treatments have limitations.
- Herbal remedies like Agnus castus are explored for fertility support.
Purpose of the Study:
- To evaluate the efficacy of Mastodynon (Agnus castus) in women with fertility disorders.
- To compare Mastodynon's effectiveness against a placebo in a double-blind study.
Main Methods:
- A prospective, randomized, placebo-controlled, double-blind study.
- 96 women with secondary amenorrhea, luteal insufficiency, or idiopathic infertility participated.
- Participants received Mastodynon or placebo for 3 months.
Main Results:
- The primary outcome (pregnancy or menstruation) was achieved in 57.6% of the Mastodynon group versus 36.0% in the placebo group (p=0.069).
- 15 women conceived during the study; pregnancy rates were more than double in the Mastodynon group for amenorrhea and luteal insufficiency.
- No significant hormonal changes were observed, and few adverse effects were reported.
Conclusions:
- Mastodynon may be a beneficial treatment for women with infertility linked to secondary amenorrhea and luteal insufficiency.
- A treatment duration of 3 to 6 months is suggested.
- Further research may explore its role in idiopathic infertility.