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[Non-specific immunologic reactivity among patients with primary multiple malignant neoplasms]
Voprosy Onkologii
|January 1, 1976
Summary
Multiple malignant tumors impact allergic reactions. Early skin tumors correlate with high allergic responses, but this decreases with more tumors or internal organ involvement.
Area of Science:
- Oncology
- Immunology
Background:
- Multiple primary malignant tumors present complex clinical challenges.
- Assessing immune response in patients with multiple neoplasms is crucial for understanding disease progression.
Purpose of the Study:
- To investigate the relationship between the number of primary malignant tumors and delayed allergic reactions.
- To evaluate the correlation between skin tumor burden and immune responsiveness using specific tests.
Main Methods:
- Seventy-four patients with various combinations of primary multiple malignant tumors were studied.
- Delayed allergic reactions were assessed using 2,4-dinitrochlorobenzene (DNCB).
- Percutaneous test with trypan blue (QD) was employed to quantify immune response.
Main Results:
- Patients with two skin tumor nodes exhibited a high incidence of delayed allergic reactions to DNCB.
- A high coefficient of the percutaneous test with trypan blue (QD) was correlated with these reactions.
- These immune response indicators diminished with the appearance of a third or more skin tumor nodes.
- In cases of polyneoplasia involving internal organs, delayed allergic reactions were absent, and QD was markedly reduced.
Conclusions:
- The number and location of primary malignant tumors significantly influence delayed allergic reactions.
- Immune responsiveness, as measured by DNCB and QD tests, appears to decrease with increasing tumor burden, particularly when internal organs are involved.