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Updated: Aug 10, 2026
08:47
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
[Comparative allergologic studies in treated antihypertensive patients with vasomotor rhinitis]
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|September 1, 1976
Summary
Allergic mechanisms may cause nasal obstruction in patients treated for hypertension. Lymphocyte transformation tests confirmed sensitization in all patients, supported by other diagnostic methods, linking drug sensitivity to symptoms.
Area of Science:
- Allergology
- Pharmacology
- Immunology
Background:
- Nasal obstruction is a common symptom in patients undergoing antihypertensive treatment.
- The role of allergic mechanisms in this specific patient group remains unclear.
Purpose of the Study:
- To investigate the potential involvement of allergologic mechanisms in nasal obstruction among antihypertensive drug recipients.
- To determine if drug sensitization correlates with the development of nasal symptoms.
Main Methods:
- Comparison of three diagnostic methods: lymphocyte transformation test (LTT), serologico-nephelometric two-step method (Hoigné), and rat mast cell degranulation test.
- Testing conducted on patients with antihypertensive treatment experiencing nasal obstruction.
Main Results:
- Lymphocyte transformation test confirmed drug sensitization in 100% of symptomatic patients (7/7).
- Positive results from Hoigné's method and the mast cell degranulation test in 5 out of 7 patients.
- Findings suggest a link between drug sensitization and nasal symptoms.
Conclusions:
- Allergologic mechanisms, specifically drug sensitization, likely contribute to nasal obstruction in patients treated for hypertension.
- Diagnostic tests like LTT can effectively identify sensitization to medications in this context.
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