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The effect of nitrogen mustard on human mononuclear blood cells

A Odegaard, J Lamvik

    Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
    |October 1, 1976
    PubMed

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    Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.