Determination of the functional hierarchy in multifocal epilepsy

An averaging technique of epileptic spikes, carried out on human stereoelectroencephalographic explorations, allowed the detection of morphological alterations of spikes peculiar to a given structure, associated with variations of temporal relations among spikes simultaneously recorded in different structures. On the basis of experimental data it can be supposed that these variations reflect the alternance of the functional prevalence among the different structures involved in the epileptic process.