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Related Experiment Videos

Urinary creatinine excretion and lean body mass

G B Forbes, G J Bruining

    The American Journal of Clinical Nutrition
    |December 1, 1976
    PubMed
    Summary

    Urinary creatinine excretion strongly correlates with lean body mass, offering a reliable estimation method. This study validates using creatinine levels to assess lean body mass in adults and children.

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    Area of Science:

    • Biomedical science
    • Human physiology
    • Biochemistry

    Background:

    • Lean body mass (LBM) is a crucial indicator of metabolic health and nutritional status.
    • Accurate LBM measurement is essential for clinical assessments and research.
    • Current methods for LBM determination can be complex or inaccessible.

    Purpose of the Study:

    • To investigate the correlation between lean body mass and urinary creatinine excretion.
    • To establish urinary creatinine as a potential non-invasive biomarker for LBM estimation.
    • To validate this method across both adult and pediatric populations.

    Main Methods:

    • Lean body mass was determined using potassium-40 (40K) whole-body counting.
    • Urinary creatinine excretion was measured from consecutive 3-day urine collections.
    • Technical errors were minimized by averaging multiple 40K assays and urine collections.

    Main Results:

    • A highly significant positive correlation (r = 0.988) was observed between LBM and urinary creatinine excretion.
    • The methodology employed reduced the impact of technical variability.
    • The findings suggest a robust relationship applicable to diverse age groups.

    Conclusions:

    • Urinary creatinine excretion provides a reliable and accessible estimate of lean body mass.
    • This method offers a practical alternative for LBM assessment in clinical and research settings.
    • Further validation in larger and more diverse cohorts is warranted.

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