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Related Experiment Videos

Canine bladder cancer: epidemiologic features

H M Hayes

    American Journal of Epidemiology
    |December 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Canine bladder cancer, primarily transitional cell carcinoma, affects certain breeds disproportionately. Monitoring dog bladder cancer may offer early warnings for human environmental hazards.

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    Area of Science:

    • Veterinary Medicine
    • Oncology
    • Epidemiology

    Background:

    • Primary bladder cancer in dogs is a significant concern.
    • Understanding risk factors and disease patterns is crucial for both canine and human health.
    • Canine bladder cancer shares epidemiological similarities with human bladder cancer.

    Purpose of the Study:

    • To investigate the epidemiologic features of primary bladder cancer in dogs.
    • To identify breeds with increased risk for bladder cancer.
    • To compare canine bladder cancer with human bladder cancer and assess its potential as a sentinel for environmental hazards.

    Main Methods:

    • Retrospective study of medical records from 13 veterinary university hospital clinics.
    • Inclusion of 114 dogs with microscopically confirmed primary bladder malignancy.

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  • Matching cases with controls to assess risk factors and associations.

    • Main Results:

    • The majority of canine bladder tumors were transitional cell carcinomas.
    • No increased frequency of urogenital tumors or anomalies was associated with bladder neoplasms.
    • Four specific dog breeds were identified with excessive risk for bladder cancer.
    • An excess of bladder cancer was observed in female dogs compared to males.

    Conclusions:

    • Certain breeds may serve as valuable models for studying genetic determinants of bladder cancer, such as abnormal tryptophan metabolism.
    • Differences in urination frequency between sexes might contribute to the observed excess in female dogs.
    • Canine bladder cancer surveillance could potentially serve as an early indicator of environmental carcinogens affecting human health.