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Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic
L Negri1, R Lattanzi, F Tabacco
1Institute of Medical Pharmacology, University "La Sapienza" of Rome, P.le Aldo Moro, 5, I-00185 Rome, Italy.
Journal of Medicinal Chemistry
|February 13, 1999
Abstract:
In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.