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Assay for Adhesion and Agar Invasion in S. cerevisiae
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Published on: November 7, 2006

Adhesion of Helicobacter pylori to yeast cells

R Ansorg1, E N Schmid

  • 1Institut für Medizinische Mikrobiologie, Universität Essen, Germany.

Zentralblatt Fur Bakteriologie : International Journal of Medical Microbiology
|February 13, 1999
PubMed

Insights

Direct interaction between Helicobacter pylori (H. pylori) and yeasts does not appear to influence H. pylori infections. Studies found limited H. pylori adhesion to most yeasts, with no significant role indicated in infection progression.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Helicobacter pylori (H. pylori) is a significant human pathogen.
  • The role of co-infections with yeasts in modulating H. pylori infections is not well understood.

Purpose of the Study:

  • To investigate the direct interaction between H. pylori and various yeast species.
  • To determine if yeast adhesion influences the course of H. pylori infections.

Main Methods:

  • Assessing the adhesion of H. pylori to Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis, Candida tropicalis, and Saccharomyces cerevisiae.
  • Utilizing electron microscopy to visualize H. pylori-yeast cell interactions.
  • Examining the effect of cholesterol depletion on H. pylori adhesion.

Main Results:

  • H. pylori demonstrated significantly higher adhesion to Candida tropicalis (adhesion ratio > 10%) compared to other yeasts (< 5%).
  • No significant difference in adhesion ratios was observed between H. pylori and yeasts compared to E. coli and S. aureus.
  • Electron microscopy revealed knob-like structures and surface-to-surface contact between H. pylori and C. tropicalis.
  • Cholesterol levels in H. pylori did not affect adhesion to yeast cells.

Conclusions:

  • Direct cooperation between H. pylori and yeasts does not appear to play a significant role in H. pylori infections.
  • Candida tropicalis showed the highest level of H. pylori adhesion among the tested yeasts.

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