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Published on: July 21, 2009
Direct-to-vial use of the AutoCyte PREP liquid-based preparation for cervical-vaginal specimens in three European
P Vassilakos1, J Saurel, R Rondez
1Center for Cytology and Clinical Pathology, University Hospital, Geneva, Switzerland. vassilakos@cytopath.int.ch
Objective:
To compare the AutoCyte PREP direct-to-vial procedure to the conventional Pap smear in two large and similar patient groups compiled from the testing experience of three cytology laboratories in Switzerland and France.
Study Design:
Randomly selected, large patient groups were evaluated using either the conventional Pap smear or the AutoCyte PREP direct-to-vial liquid-based preparation. Results were then compared statistically as to disease detection and sample adequacy.
Results:
Specimen adequacy was greatly improved in the group tested with the AutoCyte PREP. PREP also demonstrated a significant reduction in ASCUS and ASCUS:LSIL+ ratios. The three laboratories participating in this review found significantly improved detection of both low and high grade SIL. Routine use of AutoCyte PREP for cervical cytology screening offers substantial improvements in adequacy and disease detection.
