Related Experiment Video
Updated: Sep 2, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Breast-feeding and infant illness: a dose-response relationship?
J Raisler1, C Alexander, P O'Campo
1Nurse-Midwifery Program, University of Michigan School of Nursing, Ann Arbor 48109-0482, USA. jraisler@umich.edu
Insights
Full breast-feeding offers significant protection against infant illness, including diarrhea and respiratory issues. This health benefit applies across all income levels, with minimal breast-feeding showing no protective effect.
Area of Science:
- Pediatrics
- Public Health
- Infant Nutrition
Background:
- Breast-feeding is widely recognized for its health benefits.
- Understanding the dose-response relationship and socioeconomic disparities in breast-feeding benefits is crucial for public health initiatives.
Purpose of the Study:
- To investigate if breast-feeding provides a dose-related protective effect against infant illnesses.
- To determine if breast-feeding offers unique health advantages to infants from lower socioeconomic backgrounds.
Main Methods:
- Analysis of data from 7092 infants using the National Maternal and Infant Health Survey.
- Generalized estimating equations regression was employed to assess the association between breast-feeding dose and illness in the first six months of life.
- Breast-feeding dose was categorized into five levels: full, most, equal, less, and no breast-feeding.
Main Results:
- Full breast-feeding was linked to significantly lower odds of diarrhea, cough or wheeze, and vomiting.
- Infants with full, most, or equal breast-feeding showed reduced rates of certain illnesses, particularly if they were without siblings.
- No significant reduction in illness rates was observed for infants with minimal (less) breast-feeding.
- The protective effects of breast-feeding did not differ based on household income.
Conclusions:
- Full breast-feeding is associated with the lowest rates of infant illness.
- Minimal breast-feeding (less than full) does not appear to offer protective health benefits.
- Breast-feeding provides comparable health advantages to infants across all economic strata.
Objectives:
The purpose of this study was to determine whether breast-feeding has a dose-related protective effect against illness and whether it confers special health benefits to poor infants.
Methods:
The association between breast-feeding dose and illnesses in the first 6 months of life was analyzed with generalized estimating equations regression for 7092 infants from the National Maternal and Infant Health Survey. Breast-feeding dose (ratio of breast-feedings to other feedings) was categorized as full, most, equal, less, or no breast-feeding.
Results:
Compared with no breast-feeding, full breast-feeding infants had lower odds ratios of diarrhea, cough or wheeze, and vomiting and lower mean ratios of illness months and sick baby medical visits. Most breast-feeding infants had lower odds ratios of diarrhea and cough or wheeze, and equal breast-feeding infants had lower odds ratios of cough or wheeze. Full, most, and equal breast-feeding infants without siblings had lower odds ratios of ear infections and certain other illnesses, but those with siblings did not. Less breast-feeding infants had no reduced odds ratios of illness. Findings did not vary by income.
Conclusions:
Full breast-feeding was associated with the lowest illness rates. Minimal (less) breast-feeding was not protective. Breast-feeding conferred similar health benefits in all economic groups.
More Related Videos
08:12Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
Related Concept Videos
Vaccinations
Factors Affecting Illness
For instance, risk factors are connected to illness, disability,...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Drug Dosing: Infants and Children
Dose Response Curve: Conventional Versus Nonmonotonic
Development of Human Microbiota