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Related Experiment Videos

[Interventional trial for cancer prevention]

H Ishikawa1

  • 1Dept. of Cancer Epidemiology, Osaka Medical Center for Cancer and Cardiovascular Diseases.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 13, 1999
PubMed
Summary

This study investigated wheat bran biscuits for colorectal cancer prevention. Adding biscuits to dietary guidance may reduce tumor recurrence in high-risk patients.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Preventive Medicine

Background:

  • Colorectal cancer (CRC) prevention research utilizes observational and interventional study designs.
  • Identifying effective interventions for CRC recurrence is crucial for patient outcomes.

Purpose of the Study:

  • To establish a protocol for an interventional randomized controlled trial (RCT) focused on preventing colorectal cancer recurrence.
  • To evaluate the efficacy of dietary guidance alone versus dietary guidance combined with wheat bran biscuits.

Main Methods:

  • A randomized controlled trial was designed involving 200 patients with multiple colorectal tumors (adenoma and/or early cancer).
  • Participants were assigned to two groups: Regimen I (dietary guidance alone) and Regimen II (dietary guidance plus wheat bran biscuits).
  • The primary endpoint was the recurrence of colorectal tumors assessed at 2 and 4 years post-intervention.

Main Results:

  • Recruitment involved 115 patients for Regimen I and 116 patients for Regimen II over a 4-year period.
  • Data on tumor recurrence rates for both regimens are pending final analysis at the 2- and 4-year marks.

Conclusions:

  • The study established a robust RCT protocol for investigating CRC prevention strategies.
  • The trial's findings on wheat bran biscuits' role in preventing colorectal tumor recurrence are anticipated.

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