Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and autoimmune disease

L A O'Reilly1, A Strasser

  • 1Walter and Eliza Hall Institute of Medical Research, Victoria, Australia. oreilly@wehi.edu.au

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|February 13, 1999
PubMed
Summary

Programmed cell death, or apoptosis, is a genetically controlled, evolutionarily conserved process. Deregulation of apoptosis is linked to diseases like cancer and autoimmunity, with research aiming for therapeutic interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Leukemia·2016
Same author

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.

Leukemia·2016
Same author

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.

Cell death & disease·2016
Same author

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.

Cell death and differentiation·2016
Same author

Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.

Oncogene·2015
Same author

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK.

Cell death & disease·2015

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Programmed cell death (apoptosis) has been recognized since 1842, with significant research acceleration since 1972.
  • Genetic, biochemical, and cellular studies reveal apoptosis as an active, genetically controlled process conserved across species like mammals, nematodes, and fruit flies.
  • Apoptosis involves conserved regulatory genes and signaling pathways converging on effector caspases, highlighting its evolutionary significance.

Purpose of the Study:

  • To review the current understanding of the molecular regulation of apoptosis.
  • To focus on the role of defective cell death control in autoimmune diseases.
  • To explore potential therapeutic strategies targeting apoptosis for various diseases.

Main Methods:

  • Literature review of genetic, biochemical, and cellular analyses of apoptosis.
  • Analysis of conserved apoptosis-regulating genes and signaling pathways.
  • Examination of the link between apoptosis deregulation and diseases such as cancer and autoimmunity.

Main Results:

  • Apoptosis is an evolutionarily conserved, genetically regulated process involving multiple signaling pathways.
  • Caspase activation is a crucial final step in the apoptotic machinery.
  • Deregulation of apoptosis is implicated in diseases including cancer and autoimmune disorders.

Conclusions:

  • Understanding apoptosis molecular regulation is key to disease intervention.
  • Defective apoptosis control is a significant factor in autoimmunity.
  • Targeting apoptosis pathways offers potential therapeutic avenues for neoplastic, autoimmune, and degenerative diseases.

Related Experiment Videos