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Updated: Aug 19, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
Effect of methotrexate on tubal epithelium. A report of three cases
F Lécuru1, F Robin, R Taurelle
1Gynecologic and Obstetric Service, Boucicaut Hospital, Paris, France. fabrice.lecuru@bcc.ap-hop-paris.fr
Background:
Tubal effects of methotrexate injections have been poorly reported.
Cases:
Three fallopian tubes were examined with light microscopy 9-13 months after tubal methotrexate injection (one case) and intramuscular methotrexate injection (two cases) given for the treatment of unruptured ectopic pregnancies. No evidence of tubal damage was found.
Conclusion:
These three cases confirm previous experimental and clinical data showing the absence of a direct adverse effect of methotrexate on the fallopian tubes in the treatment of ectopic pregnancy.
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