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Synthetic inhibitors of DNA topoisomerase I and II
H Katayama1, Y Kawada, K Kaneko
1Niigata College of Pharmacy, Japan.
Chemical & Pharmaceutical Bulletin
|February 13, 1999
Abstract:
A new type of synthetic inhibitor of DNA topoisomerase I and II was examined and several of these derivatives exhibited strong dual activity against these enzymes. This series of compounds showed high cytotoxic activities against cancer cells, but only a limited number of compounds showed any noticeable activity in an in vivo test against murine P388. Non-specific toxicity was observed in the in vivo tests.