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Anaphylaxis to omeprazole

P A Galindo1, J Borja, F Feo

  • 1Allergy Section, Hospital Complex, Ciudad Real, Spain.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|February 13, 1999
PubMed
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Omeprazole can cause anaphylaxis, a severe allergic reaction. This study confirms omeprazole-induced anaphylaxis with positive skin tests and elevated tryptase, suggesting an IgE-mediated mechanism and potential cross-reactivity with lansoprazole.

Area of Science:

  • Pharmacology
  • Allergy and Immunology

Background:

  • Omeprazole, a proton pump inhibitor, acts on H+-K+-adenosine triphosphatase.
  • Previous reports documented rare instances of angioedema, urticaria, and anaphylaxis associated with omeprazole use.

Observation:

  • A novel case of anaphylaxis following omeprazole administration is presented.
  • The patient exhibited symptoms of anaphylaxis after omeprazole exposure.

Findings:

  • Elevated serum tryptase levels (5.1 U/L) were observed six hours post-anaphylaxis onset.
  • Positive intradermal skin tests were recorded for intravenous omeprazole, diluted omeprazole capsules, and lansoprazole.
  • Serum-specific IgE anti-omeprazole levels were negative.

Implications:

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  • The findings support omeprazole as the causative agent for anaphylaxis, likely via an IgE-mediated hypersensitivity to the drug itself.
  • Demonstrated cross-reactivity between omeprazole and lansoprazole via skin testing warrants further investigation.
  • This case highlights the importance of considering omeprazole in the differential diagnosis of anaphylaxis.