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Squalene and its potential clinical uses

G S Kelly

    Alternative Medicine Review : a Journal of Clinical Therapeutic
    |February 13, 1999
    PubMed
    Summary

    Squalene, a natural compound, shows promise in boosting immune function and potentially aiding cancer therapy. Further human trials are needed to confirm its anti-cancer properties and cholesterol-lowering effects.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Dermatology

    Background:

    • Squalene is an isoprenoid metabolite crucial for cholesterol synthesis.
    • It is abundant in human skin, acting as a UV radiation protectant.
    • Squalene is absorbed from diet and transported via lipoproteins.

    Purpose of the Study:

    • To review the biological roles and potential therapeutic applications of squalene.
    • To explore squalene's effects on immune function, lipid levels, and cancer.
    • To highlight the need for human clinical trials.

    Main Methods:

    • Literature review of existing epidemiological, experimental, and animal studies.
    • Analysis of squalene's biochemical properties and tissue distribution.
    • Examination of reported effects on immune response and lipid metabolism.

    Main Results:

    • Squalene enhances cellular and non-specific immune functions in animals.
    • It may reduce cholesterol and triglyceride levels in animals and humans.
    • Squalene acts as a singlet oxygen quencher in skin and may sequester xenobiotics.

    Conclusions:

    • Squalene demonstrates potential as an immune-boosting agent and adjunct in cancer therapy.
    • Its cholesterol-lowering effects may potentiate statin drugs.
    • Human clinical trials are essential to validate squalene's therapeutic efficacy, particularly in oncology.

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