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Relationship between myometrial resistance artery behavior and circulating lipid composition
R G Hayman1, N Sattar, A Y Warren
1School of Human Development, City Hospital, Nottingham University, United Kingdom.
American Journal of Obstetrics and Gynecology
|February 13, 1999
Summary
Preeclampsia alters myometrial vessel relaxation via plasma changes. Aberrant lipid metabolism, specifically apolipoprotein A1 levels, is linked to this endothelial dysfunction in pregnancy.
Area of Science:
- Reproductive biology
- Vascular physiology
- Lipid metabolism
Background:
- Preeclampsia is a pregnancy complication affecting maternal vascular health.
- Endothelial dysfunction is a hallmark of preeclampsia.
- The role of plasma lipids in myometrial vascular changes during preeclampsia requires further investigation.
Purpose of the Study:
- To investigate if inducible changes in myometrial vessel endothelium-dependent relaxation correlate with plasma lipid composition in preeclampsia.
- To determine the impact of preeclamptic plasma on myometrial vascular function.
Main Methods:
- Myometrial resistance vessels from 10 women with normal pregnancy were used.
- Vessels were incubated with plasma from women with preeclampsia or normal pregnancy.
- Endothelium-dependent relaxation in response to bradykinin was measured using a wire myograph.
Main Results:
- Vessels incubated with preeclamptic plasma showed significantly reduced endothelium-dependent relaxation (P =.0001).
- No significant differences in overall lipid profiles were observed between groups.
- A significant correlation was found between vessel relaxation and plasma apolipoprotein A1 levels (R2 = 0.36, P = .025).
Conclusions:
- Plasma from women with preeclampsia can impair myometrial vessel endothelium-dependent relaxation.
- The relationship between apolipoprotein A1 and endothelial function suggests a role for aberrant lipid metabolism in preeclampsia-related endothelial dysfunction.