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Anticipation in schizophrenia

A Heiden1, U Willinger, J Scharfetter

  • 1Department of General Psychiatry, University Hospital for Psychiatry, Vienna, Austria.

Schizophrenia Research
|February 16, 1999
PubMed
Summary

Anticipation, a genetic phenomenon, was observed in schizophrenia spectrum disorders. Later generations showed earlier onset and increased illness severity compared to earlier generations.

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Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Anticipation, characterized by increased disease severity and earlier onset in successive generations, is noted in genetic disorders.
  • The schizophrenia spectrum encompasses a range of related psychotic disorders.

Purpose of the Study:

  • To investigate the phenomenon of anticipation in families with schizophrenia spectrum disorders.
  • To determine if earlier generations exhibit later onset and less severe illness compared to index generations.

Main Methods:

  • Studied 15 families with schizophrenia spectrum disorders (123 individuals total).
  • Compared illness severity and age at onset between the parental generation (PG) and index generation (IG).
  • Controlled for potential birth cohort effects using a separate patient sample.

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Main Results:

  • Significant differences in illness severity (p = 0.001) and age at onset (p = 0.0001) were found between IG and PG.
  • Index generation (IG) showed significantly earlier onset (21.6 years) than the parental generation (PG) (40.2 years).
  • A control sample confirmed that birth cohort did not influence age at onset.

Conclusions:

  • Anticipation is a significant factor in the familial form of schizophrenia.
  • Further molecular research, particularly on trinucleotide repeats, is warranted to understand the mechanisms of anticipation in schizophrenia.