Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Schizophrenia, substance use, and brain morphology

G Scheller-Gilkey1, R R Lewine, J Caudle

  • 1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. gschell@emory.edu

Schizophrenia Research
|February 16, 1999
PubMed
Summary

Schizophrenia patients with substance abuse showed fewer brain abnormalities than those without, suggesting a complex relationship between brain morphology, substance use, and schizophrenia outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A biophysical analog for explosive decompression studies in animals.

Medical Research report. United States. Navy. Mine Defense Laboratory. Medical Research Dept·2014
Same author

A novel approach to sexing bovine blastocysts using male-specific gene expression.

Theriogenology·2012
Same author

Heredity in the Psychoneuroses (Summary).

Proceedings of the Royal Society of Medicine·2009
Same author

Racial effects on neuropsychological functioning in schizophrenia.

The American journal of psychiatry·2000
Same author

Double jeopardy: schizophrenia and substance use.

The American journal of drug and alcohol abuse·2000
Same author

Age at onset and sex differences in corpus callosum area in schizophrenia.

Schizophrenia research·2000

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Comorbid substance abuse is common in schizophrenia, leading to poor patient outcomes.
  • The underlying reasons for substance abuse in schizophrenia patients remain unclear.
  • Schizophrenia's clinical heterogeneity may correlate with brain morphology differences.

Purpose of the Study:

  • To investigate the association between substance abuse and brain morphology in schizophrenia patients.
  • To test the hypothesis that schizophrenia patients with substance abuse have more gross brain abnormalities.

Main Methods:

  • Qualitative analysis of magnetic resonance imaging (MRI) scans.
  • Examined a sample of 176 schizophrenia patients.
  • Compared brain abnormalities in patients with and without substance abuse history.

Related Experiment Videos

Main Results:

  • Patients abusing alcohol and drugs had a lower rate of gross brain abnormalities (8%) compared to non-substance-abusing patients (19%).
  • This trend, while not statistically significant, suggests substance abuse may be linked to less impairment in certain brain areas.
  • Findings contradict previous research linking substance abuse to more severe schizophrenia symptoms and poorer outcomes.

Conclusions:

  • Substance abuse in schizophrenia may be associated with less severe brain abnormalities, potentially indicating better premorbid adjustment.
  • Further research is needed to reconcile these findings with existing literature on substance abuse severity and outcomes in schizophrenia.