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Transcutaneous electrohepatogram in humans

¹Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt.

Frontiers in Bioscience : a Journal and Virtual Library

|February 17, 1999

Summary

Researchers developed a percutaneous method to record the electrohepatogram (EHG) in humans. This non-invasive technique successfully characterized normal liver activity, paving the way for diagnosing liver diseases.

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Area of Science:

Medical Devices
Hepatology
Biomedical Engineering

Background:

A normal electrohepatogram (EHG) in a canine model consists of monophasic, positively deflected slow waves (pacesetter potentials or PPs).
Dysrhythmic EHG patterns were observed in canines following liver insults like vessel clamping or irradiation.
Electrohepatography holds potential as an investigative tool for human liver diseases.

Purpose of the Study:

To develop and characterize a percutaneous electrohepatogram (EHG) in humans.
To assess the feasibility of non-invasive EHG recording for liver disease diagnosis.

Main Methods:

Twenty-three healthy volunteers and 13 patients with ventral hernias underwent EHG recording during surgery.
Three electrodes were sutured to the liver capsule and later placed percutaneously on the skin.
Optimal electrode placement for percutaneous recording was identified 1.5-2 cm below the costal margin.

Main Results:

Monophasic, positively deflected PPs were recorded both directly from the liver and percutaneously.
The percutaneous EHG in humans exhibited a mean frequency of 8.3 cycle/s and amplitude of 56.5 microV.
Percutaneously recorded waves were identical to those recorded directly from the liver.

Conclusions:

A normal percutaneous electrohepatogram (EHG) in humans can be characterized.
This non-invasive method shows promise for detecting changes associated with liver diseases.
Percutaneous EHG may serve as a valuable diagnostic tool for various hepatic conditions.

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