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Updated: Aug 8, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters

G Stuhler1, A Zobywalski, F Grünebach

  • 1University of Tübingen, Medical Clinic II, Otfried-Müller Strasse 10, 72076 Tübingen, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|February 17, 1999
PubMed
Summary

Dendritic cells (DC) use CD40 signaling to help activate cytolytic T lymphocytes. CD27L/CD70 on T cells regulates CD40L on helper T cells, initiating immune responses through coordinated cell activation.

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