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Rhabdomyosarcoma of the urachus. A case report
S Yokoyama1, Y Hayashida, J Nagahama
1Department of Laboratory Medicine, Oita Medical University, Japan.
Acta Cytologica
|July 1, 1997
Summary
This study presents a rare case of embryonal rhabdomyosarcoma of the urachus in a child. Diagnosis was confirmed through cytology and histology, highlighting key immunohistochemical markers for accurate identification.
Area of Science:
- Pediatric Oncology
- Cytopathology
- Skeletal Muscle Pathology
Background:
- Rhabdomyosarcoma of the urachus is an exceptionally rare pediatric malignancy.
- This report details a case of embryonal rhabdomyosarcoma arising from the urachus in a 2-year-old boy.
Observation:
- Cytologic analysis revealed small, round malignant cells with scant cytoplasm in a myxoid background.
- Histologic examination confirmed the diagnosis of embryonal rhabdomyosarcoma.
Findings:
- Immunohistochemistry showed tumor cells were positive for desmin and alpha-sarcomeric muscle actin, but negative for myoglobin.
- Cytologic samples fixed in ethanol proved more valuable than formalin-fixed histologic samples for immunochemical analysis.
Implications:
- Accurate diagnosis of pediatric small round cell tumors relies on specific markers like desmin and alpha-sarcomeric actin.
- This case contributes to understanding the rare urachal rhabdomyosarcoma and emphasizes diagnostic techniques.