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Inhibition of transforming growth factor-beta 2 expression with phosphorothioate antisense oligonucleotides in U937
1Department of Biochemistry, Kyungpook National University, Taegu, Korea.
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-beta 2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-beta 2 expression in U937 cells.