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A study of novel antiallergic agents with eosinophilic infiltration inhibiting action
N Kawasaki1, H Miyataka, H Matsumoto
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
The antiallergic action of a series of novel mono-O-substituted trimethylhydroquinones was investigated. Among this series of the compounds, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6- trimethylphenol (compound 3) showed a potent antihistaminic action (pA2 = 7.11) and an antiasthmatic action (100 mg/kg. p.o) on sensitized guinea pigs. Moreover, this compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized mice (100 mg/kg p.o.).