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Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines
P N Confalone1, F Jin, S A Mousa
1DuPont Pharmaceuticals Company, DuPont Experimental Station, Wilmington, DE 19880-0336, USA.
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
A series of isoxazolidines has been synthesized as mimetics of the RGD sequence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antagonists, exhibiting submicromolar potencies.