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Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells
1Department of Chemistry, Ewha Womans University, Seoul, Korea. syhan@mm.ewha.ac.kr
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.