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Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and
1Institut für Pharmazie und Lebensmittelchemie, Universität Erlangen-Nürnberg, Germany.
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.