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The infectious complications of sarcoidosis: a current perspective

R H Winterbauer, K G Kraemer

    Archives of Internal Medicine
    |December 1, 1976
    PubMed

    Insights

    Patients with sarcoidosis rarely develop infections, with aspergillosis being the most common. This study found tuberculosis and invasive fungal infections to be uncommon complications in sarcoidosis patients.

    Area of Science:

    • Pulmonary Medicine
    • Infectious Diseases

    Background:

    • Sarcoidosis is a multisystem inflammatory disease characterized by non-caseating granulomas.
    • Infectious complications in sarcoidosis patients require careful monitoring and understanding.

    Observation:

    • A study of 122 sarcoidosis patients tracked infection incidence over a mean of 7.2 years.
    • The cohort exhibited a low rate of infections requiring hospitalization.

    Findings:

    • Aspergillosis (three cases of mycetoma) was the most frequent infectious complication.
    • Pulmonary tuberculosis and disseminated herpes zoster were rare, each occurring in one patient.
    • No invasive fungal infections were observed during the follow-up period.

    Implications:

    • Aspergillosis, not tuberculosis, is the primary infectious concern in sarcoidosis.
    • Previous reports of high invasive fungal infection rates may be overstated or misattributed.
    • Distinguishing between sarcoidosis and infectious granulomatous disease is crucial for accurate diagnosis and treatment.

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