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Related Experiment Videos

Elevated IgM levels, edema, and fatigue syndrome

B J Cooper, R Patterson

    Archives of Internal Medicine
    |December 1, 1976
    PubMed
    Summary

    Two patients with hyperimmunoglobulinemia M (IgM) and eosinophilia presented with nonpitting edema and fatigue. This suggests a new, corticosteroid-responsive syndrome with significant morbidity but a benign prognosis.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Hyperimmunoglobulinemia M (IgM) is a rare primary immunodeficiency characterized by normal or elevated IgM levels but low levels of other immunoglobulin isotypes.
    • Eosinophilia, an elevated count of eosinophils, can be associated with allergic reactions, infections, and certain autoimmune or inflammatory conditions.

    Observation:

    • Two patients presented with nonpitting edema and extreme fatigue.
    • Both patients exhibited hyperimmunoglobulinemia M (IgM) and eosinophilia.
    • Additional laboratory findings included elevated erythrocyte sedimentation rate (ESR) and presence of rheumatoid factor.

    Findings:

    • One patient experienced continuous symptoms, managed effectively with low-dose prednisone.
    • The second patient had intermittent symptoms, with eosinophilia present during asymptomatic periods and decreased eosinophil counts when symptomatic.
    • Methylprednisolone reduced the duration of symptomatic episodes in the second patient.

    Implications:

    • These cases suggest a novel clinical syndrome characterized by hyper-IgM, eosinophilia, edema, and fatigue.
    • The syndrome appears to have substantial morbidity but is benign and responsive to corticosteroid therapy.
    • Further research is warranted to elucidate the pathophysiology and long-term outcomes of this newly identified condition.

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