[Neonatal jaundice occurring during infection with a Coxsackie B4 virus]

An infant, born at term, presented at the 3rd day of life an hepatitis with hepatospleomegaly, intense icterus and abnormal activities on the coagulation test. Coxsackie B 4 virus could be isolated from the urine, and later on the infant developed specific antibodies of increasing titers. The child recovered and encephalitic or myocardial involvements were not observed. The literature is reviewed and the authors underline the relative rarity but also the severity of Coxsackie B 4 infection in the neonatal period.