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Coagulation abnormalities in rheumatoid disease

D L Conn, F C McDuffie, F J Kazmier

    Arthritis and Rheumatism
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    Rheumatoid arthritis patients show signs of overcompensated intravascular coagulation and fibrinolysis (ICF). However, standard ICF tests do not reliably distinguish between rheumatoid arthritis patients with or without vasculitis.

    Area of Science:

    • Rheumatology
    • Hematology
    • Immunology

    Background:

    • Rheumatoid arthritis (RA) is a chronic inflammatory disease.
    • RA can involve systemic complications, including vasculitis.
    • The role of coagulation and fibrinolysis in RA pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate evidence of intravascular coagulation and fibrinolysis (ICF) in patients with rheumatoid arthritis.
    • To determine if ICF abnormalities can differentiate RA patients with vasculitis from those without.

    Main Methods:

    • Studied 41 RA patients (6 acute vasculitis, 13 chronic vasculitis, 22 no vasculitis).
    • Assessed plasma fibrinogen, platelet count, fibrin split products, active plasmin, and plasminogen activator activity.
    • Correlated findings with corticosteroid use.

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    Main Results:

    • Elevated plasma fibrinogen in all RA patient groups.
    • Acute vasculitis group showed elevated fibrinogen, platelet count, and fibrin split products.
    • Active plasmin detected in 12 patients, mainly with chronic vasculitis.
    • Corticosteroid use was associated with fewer abnormal coagulation tests.
    • No decompensated ICF observed in any patient.

    Conclusions:

    • Rheumatoid arthritis patients exhibit signs of overcompensated ICF.
    • Standard ICF tests do not reliably distinguish RA patients with vasculitis from those without.
    • Further research may be needed to identify specific markers for RA vasculitis.