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Related Experiment Videos

The lupus anticoagulant

M Boxer, L Ellman, A Carvalho

    Arthritis and Rheumatism
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Lupus anticoagulant, an antibody affecting blood clotting, is rarely linked to bleeding events. This review of 37 patients found few bleeding complications, even after surgery.

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    Area of Science:

    • Hematology
    • Immunology

    Background:

    • Lupus anticoagulant is an antibody associated with immune disorders.
    • Its mechanism involves inhibiting prothrombin activation.

    Purpose of the Study:

    • To review clinical and laboratory findings of lupus anticoagulant in patients.
    • To assess the association between lupus anticoagulant and bleeding complications.

    Main Methods:

    • Retrospective review of 37 patients with lupus anticoagulant.
    • Analysis of clinical outcomes, including surgical procedures and bleeding episodes.

    Main Results:

    • The study included 37 patients with lupus anticoagulant.
    • Fourteen patients had non-immune disorders.
    • Eighteen patients underwent 21 surgical procedures with only one instance of excessive bleeding.

    Conclusions:

    • Lupus anticoagulant is infrequently associated with bleeding.
    • The condition can occur in patients without immune-related disorders.