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The Journal of Physical Chemistry. B|June 1, 2019
X-ray Scattering and Coarse-Grained Simulations for Clustering and Interactions of Monoclonal Antibodies at High ConcentrationsBarton J Dear, Jonathan A Bollinger, Amjad Chowdhury, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide CoreKatrina A Bollinger, Andrew S Felts, Christopher J Brassard, et al.
Bioorganic & Medicinal Chemistry Letters|September 30, 2017
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
ACS Medicinal Chemistry Letters|October 24, 2017
Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidinesMasahito Abe, Mabel Seto, Rocco G Gogliotti, et al.
ACS Medicinal Chemistry Letters|September 27, 2017
Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMsJulie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
ACS Medicinal Chemistry Letters|August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor AntagonistMatthew Spock, Trever R Carter, Katrina A Bollinger, et al.
ACS Chemical Neuroscience|August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup CandidateJulie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
Bioorganic & Medicinal Chemistry Letters|May 23, 2019
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidateDarren W Engers, Bruce J Melancon, Allison R Gregro, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.
ACS Chemical Neuroscience|January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo EfficacyAlison R Gregro, Charlotte Park, Madeline F Long, et al.
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